Publications

  1. McKinnon CM and Mellor H (2017) The tumor suppressor RhoBTB1 controls Golgi integrity and breast cancer cell invasion through METTL7B.  BMC Cancer 17, 145. PMID.
  2. Richards M and Mellor H (2016) In vitro coculture assays of angiogenesis.  Methods Mol. Biol. 1430, 159-166. PMID.
  3. Richards M, Hetheridge C and Mellor H (2015) The formin FMNL3 controls early apical specification in endothelial cells by regulating the polarized trafficking of podocalyxin.  Curr. Biol. 27, 2325-2331.  PMID.
  4. Goggs R, Williams CM, Mellor H and Poole AW (2015) Platelet Rho GTPases – a focus on novel players, roles and relationships. Biochem. J. 466, 431-442. PMID.
  5. Fan L, Yan H, Pellegrin S, Morigen and Mellor H (2015) The Rif GTPase regulates cytoskeletal signaling from plexinA4 to promote neurite retraction. Neurosci. Lett. 590, 178-183. PMID.
  6. Allen JL and Mellor H (2015) The coculture organotypic assay of angiogenesis. Methods Mol. Biol. 1214, 265-270. PMID
  7. Miller VJ, McKinnon CM, Mellor H and Stephens DJ (2013) RNA interference approaches to examine Golgi function in animal cell culture. Methods Cell Biol. 118, 15-34.  PMID
  8. Goggs R, Savage JS, Mellor H and Poole AW (2013) The small GTPase Rif is dispensable for platelet filopodia generation in mice. PloS one. 8, e54663.  PMID
  9. Goggs R, Harper MT, Pope RJ, Savage JS, Williams CM, Mundell SJ, Heesom KJ, Bass M, Mellor H and Poole AW (2013) RhoG protein regulates platelet granule secretion and thrombus formation in mice. J. Biol. Chem. 288, 34217-34229.  PMID
  10. Hetheridge C, Scott AN, Swain RK, Copeland JW, Higgs HN, Bicknell R and Mellor H (2012) The formin FMNL3 is a cytoskeletal regulator of angiogenesis. J. Cell Sci. 125, 1420-1428.  PMID.
  11. Fan L and Mellor H (2012) The small Rho GTPase Rif and actin cytoskeletal remodelling. Biochem. Soc. Trans. 40, 268-272.  PMID
  12. Hetheridge C, Mavria G and Mellor H (2011) Uses of the in vitro endothelial-fibroblast organotypic co-culture assay in angiogenesis research. Biochem. Soc. Trans. 39, 1597-1600.  PMID.
  13. Collazos A, Michael N, Whelan RD, Kelly G, Mellor H, Pang LC, Totty N and Parker PJ (2011) Site recognition and substrate screens for PKN family proteins. Biochem. J. 438, 535-543.  PMID.
  14. Mellor H (2010) The role of formins in filopodia formation. Biochim.Biophys. Acta. 1803, 191-200.  PMID.
  15. Fan L, Pellegrin S, Scott A and Mellor H (2010) The small GTPase Rif is an alternative trigger for the formation of actin stress fibers in epithelial cells. J. Cell Sci. 123, 1247-1252.  PMID.
  16. Scott A and Mellor H (2009) VEGF receptor trafficking in angiogenesis. Biochem. Soc. Trans. 37, 1184-1188.  PMID.
  17. Jones MC, Caswell PT, Moran-Jones K, Roberts M, Barry ST, Gampel A, Mellor H and Norman JC (2009) VEGFR1 (Flt1) regulates Rab4 recycling to control fibronectin polymerization and endothelial vessel branching. Traffic. 10, 754-766.  PMID.
  18. Scott AN, Hetheridge C, Reynolds AR, Nayak V, Hodivala-Dilke K and Mellor H (2008) Farnesyltransferase inhibitors target multiple endothelial cell functions in angiogenesis. Angiogenesis. 11, 337-346.  PMID.
  19. Pellegrin S and Mellor H (2008) Rho GTPase activation assays. Curr. Prot. Cell Biol. Chapter 14, Unit 14.18.  PMID.
  20. Passey S, Bradley A and Mellor H (2008) Escherichia coli isolated from bovine mastitis invade mammary cells by a modified endocytic pathway. Vet. Micro. 130, 151-164.  PMID.
  21. McKinnon CM, Lygoe KA, Skelton L, Mitter R and Mellor H (2008) The atypical Rho GTPase RhoBTB2 is required for expression of the chemokine CXCL14 in normal and cancerous epithelial cells. Oncogene. 27, 6856-6865.  PMID.
  22. Pellegrin S and Mellor H (2007) Actin stress fibres. J. Cell Sci. 120, 3491-3499.  PMID.
  23. Passey S, Pellegrin S and Mellor H (2007) Scanning electron microscopy of cell surface morphology. Curr. Prot. Cell Biol. Chapter 4, Unit 4.17.  PMID.
  24. Lartey J, Smith M, Pawade J, Strachan B, Mellor H and Lopez Bernal A (2007) Up-regulation of myometrial RHO effector proteins (PKN1 and DIAPH1) and CPI-17 (PPP1R14A) phosphorylation in human pregnancy is associated with increased GTP-RHOA in spontaneous preterm labor. Biol. Reprod. 76, 971-982.  PMID.
  25. Lartey J, Gampel A, Pawade J, Mellor H and Bernal A. (2006) Expression of RND proteins in human myometrium. Biol. Reprod. 75, 452-461.  PMID.
  26. Gampel A, Moss L, Jones MC, Brunton V, Norman JC and Mellor H (2006) VEGF regulates the mobilization of VEGFR2/KDR from an intracellular endothelial storage compartment. Blood. 108, 2624-2631.  PMID.
  27. Pellegrin S and Mellor H (2005) The Rho family GTPase Rif induces filopodia through mDia2. Curr. Biol. 15, 129-133.  PMID.
  28. Curnow P, Mellor H, Stephens DJ, Lorch M and Booth PJ (2005) Translocation of the cell-penetrating Tat peptide across artificial bilayers and into living cells. Biochem. Soc. Symp. 199-209.  PMID.
  29. Wherlock M, Gampel A, Futter C and Mellor H (2004) Farnesyltransferase inhibitors disrupt EGF receptor traffic through modulation of the RhoB GTPase. J. Cell Sci. 117, 3221-3231.  PMID.
  30. Sandilands E, Cans C, Fincham VJ, Brunton VG, Mellor H, Prendergast GC, Norman JC, Superti-Furga G and Frame MC (2004) RhoB and actin polymerization coordinate Src activation with endosome-mediated delivery to the membrane. Dev. Cell. 7, 855-869.  PMID.
  31. Passey S, Pellegrin S and Mellor H (2004) What is in a filopodium? Starfish versus hedgehogs. Biochem. Soc. Trans. 32, 1115-1117.  PMID.
  32. Mellor H (2004) Cell motility: Golgi signalling shapes up to ship out. Curr. Biol.14, R434-435.  PMID.
  33. Carlton J, Bujny M, Peter BJ, Oorschot VM, Rutherford A, Mellor H, Klumperman J, McMahon HT and Cullen PJ (2004) Sorting nexin-1 mediates tubular endosome-to-TGN transport through coincidence sensing of high- curvature membranes and 3-phosphoinositides. Curr. Biol. 14, 1791-1800.  PMID.
  34. Barber SC, Mellor H, Gampel A and Scolding NJ (2004) S1P and LPA trigger Schwann cell actin changes and migration. Eur. J. Neurosci. 19, 3142-3150.  PMID.
  35. Qualmann B and Mellor H (2003) Regulation of endocytic traffic by Rho GTPases. Biochem. J. 371, 233-241.  PMID.
  36. Jepson MA, Pellegrin S, Peto L, Banbury DN, Leard AD, Mellor H and Kenny B (2003) Synergistic roles for the Map and Tir effector molecules in mediating uptake of enteropathogenic Escherichia coli (EPEC) into non-phagocytic cells. Cell. Micro. 5, 773-783.  PMID.
  37. Wherlock M and Mellor H (2002) The Rho GTPase family: a Racs to Wrchs story. J. Cell Sci. 115, 239-240.  PMID.
  38. Mircescu H, Steuve S, Savonet V, Degraef C, Mellor H, Dumont JE, Maenhaut C and Pirson I (2002) Identification and characterization of a novel activated RhoB binding protein containing a PDZ domain whose expression is specifically modulated in thyroid cells by cAMP. Eur. J. Biochem. 269, 6241-6249.  PMID.
  39. Kenny B, Ellis S, Leard AD, Warawa J, Mellor H and Jepson MA (2002) Co-ordinate regulation of distinct host cell signalling pathways by multifunctional enteropathogenic Escherichia coli effector molecules. Mol. Micro. 44, 1095-1107.  PMID.
  40. Kanumilli S, Toms NJ, Venkateswarlu K, Mellor H and Roberts PJ (2002) Functional coupling of rat metabotropic glutamate 1a receptors to phospholipase D in CHO cells: involvement of extracellular Ca2+, protein kinase C, tyrosine kinase and Rho-A. Neuropharm. 42, 1-8.  PMID.
  41. Gampel A and Mellor H (2002) Small interfering RNAs as a tool to assign Rho GTPase exchange-factor function in vivo. Biochem. J. 366, 393-398.  PMID.
  42. Cozier GE, Carlton J, McGregor AH, Gleeson PA, Teasdale RD, Mellor H and Cullen PJ (2002) The phox homology (PX) domain-dependent, 3-phosphoinositide-mediated association of sorting nexin-1 with an early sorting endosomal compartment is required for its ability to regulate epidermal growth factor receptor degradation. J. Biol. Chem. 277, 48730-48736.  PMID.
  43. Heesom KJ, Gampel A, Mellor H and Denton RM (2001) Cell cycle-dependent phosphorylation of the translational repressor eIF-4E binding protein-1 (4E-BP1). Curr. Biol. 11, 1374-1379.  PMID.
  44. Cullen PJ, Cozier GE, Banting G and Mellor H (2001) Modular phosphoinositide-binding domains–their role in signalling and membrane trafficking. Curr. Biol. 11, R882-893.  PMID.
  45. Sayers LG, Katayama S, Nakano K, Mellor H, Mabuchi I, Toda T and Parker PJ (2000) Rho-dependence of Schizosaccharomyces pombe Pck2. Genes Cells 5, 17-27.  PMID.
  46. Flynn P, Mellor H, Casamassima A and Parker PJ (2000) Rho GTPase control of protein kinase C-related protein kinase activation by 3-phosphoinositide-dependent protein kinase. J. Biol. Chem. 275, 11064-11070.  PMID.
  47. Ellis S and Mellor H (2000) The novel Rho-family GTPase rif regulates coordinated actin-based membrane rearrangements. Curr. Biol. 10, 1387-1390.  PMID.
  48. Ellis S and Mellor H (2000) Regulation of endocytic traffic by rho family GTPases. Trends Cell Biol. 10, 85-88.  PMID.
  49. Ng T, Squire A, Hansra G, Bornancin F, Prevostel C, Hanby A, Harris W, Barnes D, Schmidt S, Mellor H, Bastiaens PI and Parker PJ (1999) Imaging protein kinase Calpha activation in cells. Science. 283, 2085-2089.  PMID.
  50. Gampel A, Parker PJ and Mellor H (1999) Regulation of epidermal growth factor receptor traffic by the small GTPase rhoB. Curr. Biol. 9, 955-958.  PMID.
  51. Mellor H and Parker PJ.(1998) The extended protein kinase C superfamily. Biochem. J. 332, 281-292.  PMID.
  52. Mellor H, Flynn P, Nobes CD, Hall A and Parker PJ (1998) PRK1 is targeted to endosomes by the small GTPase, RhoB. J. Biol. Chem. 273, 4811-4814.  PMID.
  53. Flynn P, Mellor H, Palmer R, Panayotou G and Parker PJ (1998) Multiple interactions of PRK1 with RhoA. Functional assignment of the Hr1 repeat motif. J. Biol. Chem. 273, 2698-2705.  PMID.
  54. Cryns VL, Byun Y, Rana A, Mellor H, Lustig KD, Ghanem L, Parker PJ, Kirschner MW and Yuan J (1997) Specific proteolysis of the kinase protein kinase C-related kinase 2 by caspase-3 during apoptosis. J. Biol. Chem. 272, 29449-29453.  PMID.
  55. Price NT, Mellor H, Craddock BL, Flowers KM, Kimball SR. Wilmer T, Jefferson LS and Proud CG (1996) eIF2B, the guanine nucleotide-exchange factor for eukaryotic initiation factor 2. Sequence conservation between the alpha, beta and delta subunits of eIF2B from mammals and yeast. Biochem. J. 318, 637-643.  PMID.
  56. Kimball SR, Mellor H, Flowers KM and Jefferson LS (1996) Role of translation initiation factor eIF-2B in the regulation of protein synthesis in mammalian cells. Prog. Nucl. Acid Res. Mol. Biol. 54, 165-196.  PMID.
  57. Flowers KM, Mellor H, Matts RL, Kimball SR and Jefferson LS (1996) Cloning and characterization of complementary and genomic DNAs encoding the epsilon-subunit of rat translation initiation factor-2B. Biochim. Biophys. Acta 1307, 318-324.  PMID.
  58. Asuru AI, Mellor H, Thomas NS, Yu L, Chen JJ, Crosby JS, Hartson SD, Kimball SR, Jefferson LS and Matts RL (1996) Cloning and characterization of cDNAs encoding the epsilon-subunit of eukaryotic initiation factor-2B from rabbit and human. Biochim. Biophys. Acta 1307, 309-317.  PMID.
  59. Flowers KM, Mellor H, Kimball SR and Jefferson LS (1995) Structure and sequence of the gene encoding the alpha-subunit of rat translation initiation factor-2B. Biochim. Biphys. Acta 1264, 163-167.  PMID.
  60. Mellor H, Kimball SR and Jefferson LS (1994) Brefeldin A inhibits protein synthesis through the phosphorylation of the alpha-subunit of eukaryotic initiation factor-2. FEBS Lett. 350, 143-146.  PMID.
  61. Mellor H, Flowers KM, Kimball SR and Jefferson LS (1994) Cloning and characterization of a cDNA encoding rat PKR, the double-stranded RNA-dependent eukaryotic initiation factor-2 kinase. Biochim. Biphys. Acta 1219, 693-696.  PMID.
  62. Mellor H, Flowers KM, Kimball SR and Jefferson, LS (1994) Cloning and characterization of cDNA encoding rat hemin-sensitive initiation factor-2 alpha (eIF-2 alpha) kinase. Evidence for multitissue expression. J. Biol. Chem. 269, 10201-10204.  PMID.
  63. Kimball SR, Karinch AM, Feldhoff RC, Mellor H and Jefferson LS (1994) Purification and characterization of eukaryotic translational initiation factor eIF-2B from liver. Biochim. Biophys. Acta 1201, 473-481.  PMID.
  64. Sharp TV, Schwemmle M, Jeffrey I, Laing K, Mellor H, Proud CG, Hilse K and Clemens MJ (1993) Comparative analysis of the regulation of the interferon-inducible protein kinase PKR by Epstein-Barr virus RNAs EBER-1 and EBER-2 and adenovirus VAI RNA. Nuc. Acids Res. 21, 4483-4490.  PMID.
  65. Mellor H, Price NT, Oldfield S, Sarre TF and Proud CG (1993) Purification and characterisation of an initiation-factor-2 kinase from uninduced mouse erythroleukaemia cells. Eur. J. Biochem. 211, 529-538.  PMID.
  66. Mellor H and Proud CG (1991) A synthetic peptide substrate for initiation factor-2 kinases. Biochem. Biophys. Res. Commun. 178, 430-437.  PMID.